Modulation of viral neuroinflammation by astrocytic RIPK3 and serine protease inhibitors
Ebba Rosendal1, Anna K Överby1
1Department of Clinical Microbiology, Umeå University, Umeå, Sweden; Laboratory for molecular infection medicine Sweden (MIMS), Umeå University, Umeå, Sweden.
Trends in Neurosciences
|October 8, 2025
Abstract:
A recent study by Lindman and colleagues highlights a cell type-specific function of receptor-interacting kinase 3 (RIPK3) in astrocytes during neurotropic flavivirus infection. Despite a proinflammatory transcriptional profile, RIPK3 in astrocytes can attenuate neuroinflammation and reduce leucocyte infiltration through upregulation of Serpin clade A member 3N (SerpinA3N), protecting mice from excessive neuroinflammation and increasing overall survival.


