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Updated: Jan 15, 2026
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
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PCsRNAdb: a comprehensive resource of small noncoding RNAs across cancers
Rende Huang1,2,3,4, Jiang Li5, Qi Cao2,6
1Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.
Nucleic Acids Research
|October 8, 2025
Summary
This study introduces PCsRNAdb, a comprehensive database of small noncoding RNAs (sncRNAs) across 19 cancer types. It provides valuable resources and analytical tools to advance cancer research beyond microRNAs.
Area of Science:
- Genomics
- Bioinformatics
- Cancer Biology
Background:
- Small noncoding RNAs (sncRNAs) regulate biological processes and diseases.
- MicroRNAs are well-studied cancer biomarkers, but other sncRNAs are less understood in oncology.
Purpose of the Study:
- To develop a user-friendly database, PCsRNAdb, for comprehensive investigation of sncRNAs in cancer.
- To provide resources and analytical tools for exploring sncRNA-cancer associations.
Main Methods:
- Collected 190 datasets (11,114 samples) from GEO/SRA across 19 cancer types.
- Built the Pan-Cancer Small Non-Coding RNA Database (PCsRNAdb).
- Integrated basic sncRNA information and advanced analytical functionalities.
Main Results:
- PCsRNAdb offers data on sncRNA sequence, length, abundance, and target genes.
- Includes functionalities for differential expression, survival, expression profiling, and network analysis.
- Provides a centralized resource for pan-cancer sncRNA research.
Conclusions:
- PCsRNAdb serves as an invaluable resource for cancer researchers.
- The platform facilitates the exploration of non-microRNA sncRNAs in cancer biology and development.
- Expected to accelerate cancer-related research by offering integrated data and analytical tools.
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