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Three-Dimensional Magnetic Resonance Imaging-Guided Localization of Hyaluronic Acid Hydrogel for Precision in
Ya-Hong Chen1, Chu-Hsin Chen1,2, Jia-Rong Zhang3
1Department of Plastic and Reconstructive Surgery, The Ninth People's Hospital of Shanghai Jiaotong University School of Medicine, 639 Zhi Zao Ju Rd, Shanghai, 200011, People's Republic of China.
Aesthetic Plastic Surgery
|October 8, 2025
Summary
Three-dimensional magnetic resonance imaging (3D-MRI) improves the precision of hyaluronidase injections for facial overfilled syndrome (FOS). While clinical results were similar, 3D-MRI offers better HA localization and reduces treatment time and sessions.
Area of Science:
- Aesthetic Medicine
- Medical Imaging
- Dermatology
Background:
- Facial overfilled syndrome (FOS) is a complication of excessive hyaluronic acid (HA) filler injections.
- Traditional hyaluronidase treatments for FOS lack precision, leading to suboptimal outcomes.
- This study investigates the use of 3D-MRI for precise HA localization and hyaluronidase administration.
Purpose of the Study:
- To evaluate the efficacy of 3D-MRI-guided hyaluronidase injections for FOS.
- To compare the precision and outcomes of guided versus non-guided hyaluronidase treatments.
- To assess patient satisfaction and safety profiles of both treatment methods.
Main Methods:
- A retrospective case-control study involving 50 patients with FOS.
- Patients were divided into two groups: 3D-MRI-guided hyaluronidase injection (M+ group, n=25) and non-guided injection (M- group, n=25).
- Outcomes were assessed using 2D/3D photography, 3D-MRI volumetric analysis, GAIS, patient satisfaction surveys, and safety evaluations.
Main Results:
- Both groups showed improved facial contours; no significant difference in GAIS scores or adverse events.
- The 3D-MRI-guided group demonstrated precise HA localization and significant volume reduction.
- The M+ group required fewer treatments and had shorter treatment durations compared to the M- group (p < 0.05).
Conclusions:
- 3D-MRI guidance enhances precision in hyaluronidase injections for FOS, providing objective HA distribution insights.
- While clinical outcomes were comparable, 3D-MRI offers a promising tool for tailored FOS treatment.
- Further research into 3D-MRI's role in aesthetic practice is warranted.
