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Updated: Jan 15, 2026

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence
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Forensic genetics in the omics era.

Manfred Kayser1

  • 1Department of Pathology and Clinical Bioinformatics, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. m.kayser@erasmusmc.nl.

Nature Reviews. Genetics
|October 8, 2025
PubMed
Summary
This summary is machine-generated.

Forensic genetics advances use omics and sequencing to analyze biological traces. These methods enhance perpetrator identification, trait prediction, and evidence characterization in criminal investigations.

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Area of Science:

  • Forensic Genetics
  • Molecular Biology
  • Genomics

Background:

  • Technological innovations have significantly improved forensic genetics.
  • An increasing number of nucleic acid markers are utilized.
  • Analysis of human biological traces is crucial in criminal investigations.

Purpose of the Study:

  • To highlight recent advances in forensic genetics.
  • To discuss the application of omics and sequencing technologies.
  • To explain the impact on analyzing biological evidence.

Main Methods:

  • Non-targeted omics approaches (genomics, transcriptomics, epigenomics, microbiome profiling).
  • Targeted massively parallel sequencing.
  • Non-targeted whole-genome sequencing.

Main Results:

  • Improved scope, accuracy, and reliability of forensic information.
  • Identification of perpetrators, including monozygotic twins, and relatives.
  • Prediction of phenotypic and behavioral traits.
  • Determination of trace characteristics like tissue type and deposition time.

Conclusions:

  • Advanced omics and sequencing technologies are revolutionizing forensic genetics.
  • These methods provide powerful tools for criminal investigations.
  • The scope of information obtainable from biological traces has expanded significantly.