Related Experiment Video
Updated: Jan 15, 2026
06:12
Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
Published on: May 3, 2024
3.2K
Epitranscriptomic modifications in programmed cell death: mechanistic insights and implications for liver diseases
Lulu Chen1, Yajuan Lu1, Aoli Deng1
1Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Cellular & Molecular Biology Letters
|October 8, 2025
Summary
Epitranscriptomic modifications regulate programmed cell death (PCD) in liver diseases. Understanding these RNA changes offers new therapeutic targets for conditions like MASLD, viral hepatitis, and HCC.
Area of Science:
- Molecular Biology
- Cell Biology
- Hepatology
Background:
- Epitranscriptomic modifications dynamically regulate RNA metabolism.
- Aberrant epitranscriptomic changes are implicated in liver disease pathogenesis.
- These modifications impact programmed cell death (PCD) pathways.
Purpose of the Study:
- To review the molecular mechanisms of epitranscriptomic modifications in PCD.
- To elucidate the role of epitranscriptomics in various liver diseases.
- To summarize current therapeutic strategies targeting epitranscriptomic modifications.
Main Methods:
- Systematic literature review.
- Analysis of molecular mechanisms linking epitranscriptomics and PCD.
- Review of drug targets and therapeutic approaches.
Main Results:
- Epitranscriptomic modifications finely tune RNA networks controlling PCD.
- Dysregulation contributes to MASLD, viral hepatitis, ALD, fibrosis, and HCC.
- These modifications present potential biomarkers and therapeutic targets.
Conclusions:
- Epitranscriptomic regulation of PCD is crucial in liver disease.
- Targeting epitranscriptomic modifications offers novel treatment avenues.
- This field provides directions for precision medicine in liver disorders.
Related Concept Videos
01:58Cell Specific Gene Expression
16.2K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.2K
01:30Overview of Cell Death
9.4K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
9.4K
01:30Apoptosis
14.1K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
14.1K
01:31Regulation of the Unfolded Protein Response
2.9K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.9K
01:18Autophagic Cell Death
4.3K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.3K
01:24Liver Regeneration
4.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.3K