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Characterizing Extracellular Vesicles from Biological Fluids
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Plant-derived extracellular vesicles: composition, function and clinical potential.

Defa Huang1, Jie Chen2, Minghong Zhao3

  • 1Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.

Journal of Translational Medicine
|October 8, 2025
PubMed
Summary
This summary is machine-generated.

Plant-derived extracellular vesicles (PDEVs) are crucial for plant functions and environmental interactions. These vesicles show significant potential for clinical applications, including drug delivery and disease diagnosis.

Keywords:
Biological roleClinical applicationExtracellular vesicleIsolation techniquePlant

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Area of Science:

  • Plant Science
  • Biomedical Research
  • Cell Biology

Background:

  • Extracellular vesicles (EVs) are membrane-bound vesicles secreted by cells.
  • Plant-derived extracellular vesicles (PDEVs) are increasingly recognized for their roles in plant physiology and intercellular communication.
  • PDEVs are involved in plant growth, development, and stress responses by transporting bioactive molecules.

Purpose of the Study:

  • To review the current literature on plant-derived extracellular vesicles (PDEVs).
  • To cover compositional characterization, isolation, purification, biological roles, and clinical applications of PDEVs.
  • To provide a theoretical basis and practical guidance for advancing PDEV research in biomedical fields.

Main Methods:

  • Literature review of existing studies on PDEVs.
  • Analysis of research on PDEV composition and isolation techniques.
  • Synthesis of information on biological functions and clinical potential.

Main Results:

  • PDEVs are involved in essential plant processes and plant-environment interactions.
  • PDEVs possess significant potential for clinical applications such as drug carriers, vaccine development, and disease biomarkers.
  • Current research highlights the need for systematic studies on PDEV characterization and application.

Conclusions:

  • Plant-derived extracellular vesicles are versatile biological nanostructures with dual roles in plants and medicine.
  • Further research into PDEV isolation, characterization, and biological functions is warranted.
  • PDEVs hold promise for innovative applications in the biomedical field.