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Related Concept Videos

Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

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Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
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Related Experiment Video

Updated: Jan 15, 2026

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment
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First Intraoperative Cardiac Catheterization During Donor Normothermic Regional Perfusion.

Kevin C McGann1, Aaron M Williams1, Kashish Goel2

  • 1From the Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|October 9, 2025
PubMed
Summary

This study introduces a new coronary angiography technique for donation after circulatory death (DCD) heart donors during normothermic regional perfusion (NRP). This innovation aims to improve donor heart assessment and increase organ utilization for transplantation.

Keywords:
donation after circulatory deathextended criteria donorheart transplantnormothermic regional perfusiontransplant coronary artery disease

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Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Surgical Innovation

Background:

  • Heart transplantation is limited by donor organ scarcity.
  • Donation after circulatory death (DCD) and extended criteria donor (ECD) allografts expand donor pools.
  • Coronary assessment in DCD hearts is often limited.

Purpose of the Study:

  • To present an innovative technique for DCD donor coronary angiography during normothermic regional perfusion (NRP).
  • To address the limitations in coronary assessment for DCD donor hearts.

Main Methods:

  • Performed on-table cardiac catheterization in a DCD heart donor.
  • Utilized normothermic regional perfusion (NRP) support during the procedure.

Main Results:

  • Successfully demonstrated a novel technique for DCD donor coronary angiography during NRP.
  • This represents the first reported instance of on-table cardiac catheterization in a DCD donor under NRP.

Conclusions:

  • The presented technique offers a potential method to enhance coronary assessment in DCD heart donors.
  • Further research is needed to establish the widespread implementation and impact of this technique on DCD organ utilization and patient survival.