Ivermectin and non-parasitic disorders: An update

Area of Science:

• Pharmacology
• Drug Discovery
• Oncology

Background:

• Ivermectin, an anti-parasitic drug, exhibits potential in treating various non-parasitic conditions.
• Its mechanisms include antiviral, anti-angiogenic, and anti-cancer properties.
• Emerging evidence suggests neuroprotective and potential cardioprotective effects.

Purpose of the Study:

• To review the current research on ivermectin's effects in non-parasitic diseases.
• To highlight its therapeutic potential in neurological, inflammatory, and neoplastic disorders.
• To address unanswered questions regarding its efficacy and safety.

Main Methods:

• Literature review of existing studies on ivermectin.
• Analysis of research focusing on ivermectin's impact on non-parasitic conditions.
• Synthesis of findings related to neurological, cardiovascular, and anti-cancer effects.

Main Results:

• Ivermectin demonstrates broad-spectrum activity against DNA and RNA viruses.
• It exhibits anti-cancer properties by inhibiting angiogenesis and inducing apoptosis.
• Neuroprotective effects in models of cerebral ischemia and Alzheimer's disease are noted, alongside anticonvulsant properties.
• Cardioprotective effects are suggested, but potential detrimental impacts on myocardial ischemia require further investigation.

Conclusions:

• Ivermectin possesses significant therapeutic potential for a range of non-parasitic diseases.
• Further investigation is crucial to elucidate its precise mechanisms and clinical applications.
• Understanding both beneficial and adverse effects is essential for future therapeutic strategies.