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Visual Recovery in Leber's Hereditary Optic Neuropathy Plus: A Case Report and Literature Insight
Radhika Paranjpe1, Himani Yadav1, Preethi Abraham1
1Department of Ophthalmology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, India.
Case Reports in Ophthalmology
|October 9, 2025
Summary
Leber's hereditary optic neuropathy plus (LHON plus) is a rare condition causing vision loss and systemic symptoms. Early mitochondrial support, like coenzyme Q10, can significantly improve vision in affected young men.
Area of Science:
- Ophthalmology
- Genetics
- Neurology
Background:
- Leber's hereditary optic neuropathy (LHON) is a mitochondrial disorder causing vision loss, primarily in young males.
- It results from mutations in mitochondrial DNA genes, affecting Complex I in the respiratory chain.
- LHON plus encompasses optic neuropathy with additional systemic manifestations.
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