Related Experiment Video
Updated: Jan 15, 2026
The Chick Chorioallantoic Membrane In Vivo Model to Assess Perineural Invasion in Head and Neck Cancer
Published on: June 21, 2019
Metastasis of Neuroendocrine Carcinoma Masquerading as a Chalazion
Sofía Ramos-Bartolomei1, José López-Fontanet1, Sofía Muns-Aponte1
1Department of Ophthalmology, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
Introduction:
Nonhealing or rapidly growing lesions should raise suspicion for malignancy, especially in a patient with a prior history of cancer. The purpose of this case was to highlight the importance of a thorough clinical history. A high index of suspicion and low threshold for biopsy are important, as is a fast diagnosis, as they can make a difference in adequate treatment and prognosis.
Case Presentation:
We present a case of a 46-year-old female with a history of invasive ductal carcinoma of the breast presenting with a rapidly growing painless right lower eyelid lesion with biopsy remarkable for a high-grade neuroendocrine carcinoma suspected to be a result of metastasis with rare transformation of breast ductal carcinoma.
Conclusion:
She had an eyelid lesion recurrence less than 2 months after biopsy and excision, demonstrating the importance of early detection and biopsy with immunohistochemistry to target malignant cells and improve life quality and expectancy.
