Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

794
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
794
Assessment of the Cardiovascular System II: Inspection01:29

Assessment of the Cardiovascular System II: Inspection

791
Inspection is the initial step in assessing the cardiovascular system. It involves a detailed visual examination that provides crucial information about a patient's circulatory and cardiac health. This systematic process, conducted from head to toe, helps identify signs of cardiovascular conditions by observing physical appearance, skin and mucous membranes, jugular and carotid pulsations, chest symmetry, and the condition of the extremities.
Head and Neck
791
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

538
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
538
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

878
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
878
Assessment of the Cardiovascular System I: Subjective Data01:23

Assessment of the Cardiovascular System I: Subjective Data

753
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
753
Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

812
In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
812

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expression Profiles of α1nAChR, ERK1/2, c-FOS and Matrix Metalloproteinases Among Male Smokers with Acute Coronary Syndrome.

International journal of molecular sciences·2026
Same author

Assesment of the L1 vertebra shape and size variation for age determination in the Malaysian adult population using geometric morphometric approach.

Anatomical science international·2026
Same author

A systematic review on the use of C-reactive protein in autopsy practice.

International journal of legal medicine·2024
Same author

Unveiling TIMPs: A Systematic Review of Their Role as Biomarkers in Atherosclerosis and Coronary Artery Disease.

Diseases (Basel, Switzerland)·2024
Same author

The Pattern of Injuries Among Motorcyclists in Fatal Road Traffic Accidents: An Autopsy-Based Study.

The American journal of forensic medicine and pathology·2020
Same author

Sex estimation using subpubic angle from reconstructed three-dimensional computed tomography pelvic model in a contemporary Malaysian population.

Anatomy & cell biology·2020

Related Experiment Video

Updated: Jan 15, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.4K

Relationship Between Frank's Sign and Cardiovascular Disease: An Autopsy-Based Study.

Bashirah Mohd Nor1, Wan Mohammad Hafiz Wan Razali2,3, Faridah Mohd Nor1

  • 1Forensic Unit, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MYS.

Cureus
|October 9, 2025
PubMed
Summary
This summary is machine-generated.

Frank's sign, an earlobe crease, is significantly more common in cardiovascular deaths. This finding suggests it may serve as a useful external marker for predicting cardiovascular mortality and coronary artery disease.

Keywords:
autopsycardiovascular deathcoronary artery atherosclerosisearlobe creasefrank’s sign

More Related Videos

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.6K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.0K

Related Experiment Videos

Last Updated: Jan 15, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.4K
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.6K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.0K

Area of Science:

  • Cardiology
  • Pathology
  • Dermatology

Background:

  • Frank's sign, a diagonal earlobe crease, is a potential external marker for cardiovascular disease.
  • Previous studies suggest a link between Frank's sign and fatal coronary artery disease outcomes.

Purpose of the Study:

  • To compare the prevalence of Frank's sign in cardiovascular versus non-cardiovascular deaths.
  • To assess the association between Frank's sign and critical coronary artery stenosis.

Main Methods:

  • A cross-sectional autopsy study involving 51 cardiovascular deaths and 51 matched non-cardiovascular deaths.
  • Assessment of Frank's sign presence and severity from photographs, correlated with coronary artery stenosis.
  • Statistical analysis using chi-square tests and multivariable logistic regression.

Main Results:

  • Frank's sign was significantly more prevalent in cardiovascular deaths (p < 0.001).
  • A strong association was observed between Frank's sign and critical atherosclerotic coronary artery occlusion (p < 0.001).
  • Frank's sign independently predicted critical coronary occlusion (adjusted odds ratio = 7.77, p < 0.001).

Conclusions:

  • Frank's sign is significantly associated with cardiovascular mortality due to coronary artery atherosclerosis.
  • The earlobe crease demonstrates moderate diagnostic performance for predicting cardiovascular death and critical coronary occlusion.
  • Frank's sign may serve as a valuable, non-invasive external clinical marker in cardiovascular risk assessment.