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Association Between the CALLY Index and Kidney Stones: Insights From NHANES 2007-2010
Liangliang Dai1,2, Chenjie Qiu3
1Department of Urology, Wujin Hospital Affiliated With Jiangsu University, Changzhou 213004, China.
Mediators of Inflammation
|October 9, 2025
Summary
The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index shows a significant inverse association with kidney stone risk. Higher CALLY index scores correlate with a reduced likelihood of developing kidney stones.
Area of Science:
- Nephrology
- Biomarkers
- Inflammation
Background:
- Kidney stones represent a growing health issue, with incidence linked to inflammation, diet, and immune status.
- The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index, a combined marker, has shown prognostic utility in cancer but its role in kidney stone formation is unexamined.
- This study investigates the CALLY index's association with kidney stone risk.
Purpose of the Study:
- To explore the relationship between the CALLY index and the risk of kidney stone formation.
- To analyze data from the National Health and Nutrition Examination Survey (NHANES) 2007-2010.
Main Methods:
- Utilized data from 10,562 NHANES participants (2007-2010).
- Assessed kidney stone status via self-report questionnaires.
- Employed multivariable logistic regression, restricted cubic spline (RCS) models, and subgroup analyses to evaluate the CALLY index association.
Main Results:
- Individuals with kidney stones had a lower mean CALLY index.
- A significant inverse association was found between the CALLY index and kidney stone risk.
- The highest quartile of the CALLY index was linked to a 27.3% lower risk of kidney stones compared to the lowest quartile, with a confirmed nonlinear relationship.
Conclusions:
- The CALLY index demonstrates a negative association with kidney stone risk.
- This suggests the CALLY index may serve as a potential indicator for kidney stone development.
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