Related Experiment Video

Updated: Jan 6, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

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Research progress on sirtuin family genes in colorectal cancer

Tong Liu1, Tianhua Wu1, Lijun Luo2

  • 1Department of General Surgery, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, Guangdong, China.

Frontiers in Oncology
|October 9, 2025
PubMed

Insights

Sirtuins, NAD+-dependent enzymes, have dual roles in colorectal cancer (CRC), acting as both tumor promoters and suppressors. Understanding their mechanisms offers potential for novel CRC therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Sirtuins are NAD+-dependent deacetylases regulating vital cellular functions.
  • Dysregulated sirtuin expression is linked to aging, metabolic disorders, and cancer.
  • In colorectal cancer (CRC), sirtuins exhibit context-dependent dual roles.

Purpose of the Study:

  • To systematically review research on sirtuin family genes in CRC.
  • To highlight the dual pro-tumorigenic and tumor-suppressive functions of sirtuins in CRC.
  • To elucidate the molecular mechanisms underlying sirtuin activity in CRC.

Main Methods:

  • Systematic literature review.
  • Analysis of published research on sirtuin genes in colorectal cancer.
  • Synthesis of findings on molecular mechanisms and therapeutic potential.

Main Results:

  • Sirtuins modulate CRC cell proliferation, migration, invasion, and apoptosis.
  • Sirtuins can activate pro-oncogenic pathways or suppress tumor progression in CRC.
  • Specific sirtuin family members display distinct roles in CRC development.

Conclusions:

  • Sirtuins present a complex regulatory network in CRC.
  • Sirtuins are promising therapeutic targets for precision CRC treatment.
  • Targeted sirtuin modulators combined with other therapies may offer novel CRC treatment strategies.
Keywords:
colorectal cancerepigenetic regulationmetabolic reprogrammingsirtuin familytargeted therapy

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