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Updated: Jan 15, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Immunoparesis in multiple myeloma: a current overview

Hongfeng Wang1, Jianbin Chen1

  • 1Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Frontiers in Oncology
|October 9, 2025
PubMed

Multiple myeloma (MM) is a common hematologic malignancy characterized by clonal plasma cell proliferation. Despite significant therapeutic advancements with proteasome inhibitors, immunomodulatory drugs, and anti-B-cell maturation antigen (BCMA) therapies, the disease remains largely incurable. Immunoparesis, a severe state of immune dysfunction, exhibits high prevalence in MM patients and profoundly impacts prognosis. This review summarizes the pathogenic mechanisms and clinical characteristics of immunoparalysis, with a focus on its impact on prognosis and early-onset infections, the effects of contemporary drug therapies on immunoparalysis, and immune reconstitution.

Keywords:
bone marrow microenvironmentimmune reconstitutionimmunoparesisinfectionsmultiple myelomaprognosis

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