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Alcoholic hepatitis.

L D Jewell, A Medline, N M Medline

    Canadian Medical Association Journal
    |October 9, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Fatal alcoholic hepatitis in young adults presents acutely, progressing to liver and kidney failure. Autopsies reveal enlarged, non-cirrhotic livers with specific histological markers of severe alcoholic liver disease.

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    Area of Science:

    • Hepatology
    • Pathology
    • Internal Medicine

    Background:

    • Alcoholic hepatitis is a severe liver disease associated with excessive alcohol consumption.
    • Non-cirrhotic alcoholic hepatitis can be fatal, particularly in younger individuals.
    • Understanding the pathological features is crucial for diagnosis and management.

    Purpose of the Study:

    • To present clinical and pathological data from four fatal cases of non-cirrhotic alcoholic hepatitis.
    • To highlight key histological criteria for diagnosing alcoholic hepatitis.
    • To describe the progression to hepatic and renal failure.

    Main Methods:

    • Clinical data review from four patients with fatal non-cirrhotic alcoholic hepatitis.
    • Autopsy findings including gross liver examination.

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  • Histological examination of liver tissue to identify diagnostic features.

    • Main Results:

    • Patients were relatively young with a history of excessive alcohol intake.
    • Disease onset was acute, leading to hepatic and renal failure.
    • Autopsy revealed enlarged, non-cirrhotic livers.
    • Histology showed panlobular inflammation, Mallory material, and fine fibrosis.

    Conclusions:

    • Non-cirrhotic alcoholic hepatitis can be rapidly fatal even in young patients.
    • Key histological findings include polymorphonuclear infiltrate, Mallory material, and fibrosis.
    • Central hyaline sclerosis may be observed as a consequence of centrolobular fibrosis.