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Related Experiment Video

Updated: Jan 15, 2026

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Collapsing Glomerulopathy during Pregnancy: A Case Series.

Martin Benjamin Yama Estrella1, Mario Alamilla-Sanchez1, Carolina Gonzalez-Fuentes1

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Preeclampsia can cause collapsing glomerulopathy, a kidney condition. In a study of three pregnant patients, kidney function improved after delivery without immunosuppressants, suggesting favorable outcomes post-preeclampsia resolution.

Keywords:
Collapsing glomerulopathyFocal segmental glomerulosclerosisPreeclampsiaProteinuria

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Area of Science:

  • Nephrology
  • Obstetrics
  • Pathology

Background:

  • Preeclampsia is a major cause of pregnancy morbidity, linked to glomerular endotheliosis, fibrin deposition, and thrombotic microangiopathy.
  • It presents with edema, proteinuria, and acute kidney injury, sometimes superimposed on pre-existing glomerular diseases.
  • Biopsy studies reveal de novo glomerulopathy, including collapsing glomerulopathy, in preeclampsia cases.

Purpose of the Study:

  • To report three cases of preeclampsia-associated collapsing focal and segmental glomerulosclerosis.
  • To investigate the treatment and outcomes of these specific kidney conditions during pregnancy.

Main Methods:

  • Case series reporting three pregnant patients in their third trimester with preeclampsia-associated collapsing focal and segmental glomerulosclerosis.
  • Evaluation included assessment for secondary causes of nephrotic-range proteinuria.
  • Treatment focused on antiproteinuric measures initiated post-delivery.

Main Results:

  • Two patients were previously healthy; one had a history of chronic hypertension.
  • All presented with nephrotic-range proteinuria without identifiable secondary causes.
  • Antiproteinuric treatment post-delivery led to a complete response, negating the need for immunosuppressants.

Conclusions:

  • Preeclampsia-associated collapsing glomerulopathy can resolve favorably after delivery.
  • A subgroup of pregnant patients may avoid immunosuppression if preeclampsia is managed effectively.
  • Early detection and appropriate management post-delivery can lead to positive maternal and fetal outcomes.