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Related Experiment Video

Updated: Jan 15, 2026

Functional MRI in Conjunction with a Novel MRI-compatible Hand-induced Robotic Device to Evaluate Rehabilitation of Individuals Recovering from Hand Grip Deficits

Functional MRI in Conjunction with a Novel MRI-compatible Hand-induced Robotic Device to Evaluate Rehabilitation of Individuals Recovering from Hand Grip Deficits

Published on: November 23, 2019

Mapping hand function with simultaneous brain-spinal cord functional MRI.

Valeria Oliva^1,2, Sandrine Bédard^1,3, Merve Kaptan¹

¹Division of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, United States.

Imaging Neuroscience (Cambridge, Mass.)

|October 9, 2025

Summary

This summary is machine-generated.

This study mapped brain and spinal cord activity during hand tasks. It revealed graded neural responses and inhibition patterns, advancing our understanding of motor control and potential rehabilitation strategies.

Keywords:

brain functional MRI hand strength motor activity musculoskeletal and neural physiological phenomena spinal cord

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Last Updated: Jan 15, 2026

Functional MRI in Conjunction with a Novel MRI-compatible Hand-induced Robotic Device to Evaluate Rehabilitation of Individuals Recovering from Hand Grip Deficits

Functional MRI in Conjunction with a Novel MRI-compatible Hand-induced Robotic Device to Evaluate Rehabilitation of Individuals Recovering from Hand Grip Deficits

Published on: November 23, 2019

Functional Mapping with Simultaneous MEG and EEG

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Published on: June 14, 2010

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

Published on: May 10, 2012

Area of Science:

Neuroscience
Motor Control
Neuroimaging

Background:

Hand motor control involves complex brain-spinal cord interactions.
Disruptions in these pathways lead to motor deficits.
Spinal cord mechanisms in hand function are less understood than brain mechanisms.

Purpose of the Study:

To map neural activity across the brain and spinal cord during hand strength and dexterity tasks.
To investigate brain-spinal cord interactions in motor control using simultaneous fMRI.
To characterize neural mechanisms underlying hand function and potential impairments.

Main Methods:

Simultaneous brain-spinal cord functional MRI (fMRI) was performed on 28 healthy volunteers.
Participants completed force-matching and finger-tapping tasks at varying intensities.
Brain and spinal cord images were analyzed for activation and deactivation patterns.

Main Results:

Both tasks showed activation in motor and sensory brain/spinal cord regions.
Graded responses were observed in the left primary motor (M1) and sensory (S1) cortex, and right spinal cord.
Task-level dependent deactivation was noted in the right M1/S1 and left spinal cord gray matter.

Conclusions:

The study provides a detailed map of brain-spinal cord interactions during hand tasks.
Findings suggest interhemispheric inhibition and spinal cord inhibitory mechanisms during unilateral tasks.
This research enhances understanding of motor control and may inform rehabilitation for motor impairments.