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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
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Progress in understanding how clock genes regulate aging and associated metabolic processes.

Yanhong Su1, Meng Wang1, Juan Chen1

  • 1Key Laboratory of Sports Human Science in Liaoning Province, College of Physical Education, Liaoning Normal University, Dalian, China.

Frontiers in Physiology
|October 9, 2025
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This summary is machine-generated.

Circadian rhythm disruption worsens with aging, contributing to metabolic disorders. Understanding these changes is key to developing strategies against aging and metabolic diseases.

Keywords:
agingcircadian rhythmsclock genesmetabolic disordersmetabolic syndrome

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Area of Science:

  • Chronobiology
  • Metabolic Health
  • Aging Research

Background:

  • The body's circadian system, regulated by the suprachiasmatic nucleus, involves central and peripheral clocks driven by clock genes.
  • Circadian rhythm disruption is increasingly linked to metabolic disorders.
  • Aging impairs circadian rhythm function, causing widespread metabolic dysfunction.

Purpose of the Study:

  • To review molecular mechanisms of circadian rhythm disruption during aging.
  • To analyze rhythm imbalance characteristics in metabolic organs.
  • To highlight the link between circadian rhythms, aging, and metabolic diseases.

Main Methods:

  • Literature review focusing on molecular mechanisms.
  • Analysis of circadian rhythm disruption in aging.
  • Systematic review of metabolic organ rhythm imbalance.

Main Results:

  • Aging impacts circadian rhythms through mechanisms like telomere homeostasis, SIRT1 epigenetic regulation, and NAD+ metabolism.
  • Metabolic dysfunction in aging is associated with specific patterns of circadian rhythm imbalance across organs.

Conclusions:

  • Understanding the interplay between circadian rhythms and aging is crucial.
  • Targeting circadian rhythm regulation may offer strategies for combating aging and metabolic diseases.