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Related Experiment Video

Updated: Jan 15, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

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Published on: May 10, 2021

⁶⁸Ga-DOTATATE Measurements Predict Progression of Aortic Valve Calcification in Humans.

Wesam Aldosoky¹, Shady Abohashem^1,2,3, Guillaume Goudot^1,4

¹Cardiovascular Imaging Research Center, Radiology Department (W.A., S.A., G.G., S.S.G., I.Q., E.H., O.A., J.B., G.C., M.T.O., A.T.), Massachusetts General Hospital and Harvard Medical School, Boston.

Arteriosclerosis, Thrombosis, and Vascular Biology

|October 9, 2025

Summary

Gallium-68 DOTA-(Tyr³)-octreotate (⁶⁸Ga-DOTATATE) uptake in the aortic valve indicates inflammation and predicts the progression of aortic valve calcification (AVC). This finding highlights inflammation's role in AVC progression.

Keywords:

aortic valve gallium Ga 68 dotatate inflammation positron emission tomography tomography, X-ray computed

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Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

Area of Science:

Cardiovascular Imaging
Nuclear Medicine
Inflammation Research

Background:

Inflammation is a known driver of aortic valve calcification (AVC).
⁶⁸Ga-DOTATATE positron emission tomography (PET) imaging can quantify tissue inflammation by binding to somatostatin receptors.
The prognostic value of aortic valve (AV) ⁶⁸Ga-DOTATATE uptake for AVC progression was previously unknown.

Purpose of the Study:

To investigate whether ⁶⁸Ga-DOTATATE uptake in the aortic valve predicts the progression of AVC.
To assess the diagnostic and prognostic utility of AV ⁶⁸Ga-DOTATATE uptake in patients with AVC.

Main Methods:

A total of 683 individuals underwent baseline ⁶⁸Ga-DOTATATE PET/CT imaging.
209 individuals had follow-up imaging after a median of 1.3 years.
AVC progression was defined by changes in Hounsfield units on CT scans, with progressors showing a square root difference of annualized AVC change ≥2.5.

Main Results:

Baseline AV ⁶⁸Ga-DOTATATE uptake correlated with baseline AVC.
AV ⁶⁸Ga-DOTATATE uptake significantly predicted AVC progression (OR, 3.0).
This association remained significant after adjusting for multiple clinical factors, except for age.

Conclusions:

⁶⁸Ga-DOTATATE PET/CT is a valuable tool for assessing AV inflammation.
AV ⁶⁸Ga-DOTATATE uptake serves as a predictor of AVC progression.
Findings emphasize inflammation's role in AVC and suggest potential for risk stratification and therapeutic evaluation in valvular heart disease.