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Related Concept Videos

Menopause01:28

Menopause

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
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Depression: Overview01:18

Depression: Overview

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

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Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
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Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
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Stress and Mental Health01:30

Stress and Mental Health

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Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
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Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
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Menopause and suicide: A systematic review.

Olivia Hendriks1, Jason C McIntyre1, Abigail K Rose1

  • 1School of Psychology, Liverpool John Moores University, UK.

Women'S Health (London, England)
|October 9, 2025
PubMed
Summary

The menopausal transition is linked to increased suicidality in women, especially during perimenopause. Factors like hormonal changes and mental health conditions contribute to this risk, necessitating integrated mental health support.

Keywords:
cultural and social factorshormonesmenopauseprimary ovarian insufficiencysuicidality

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Area of Science:

  • Reproductive Health
  • Mental Health
  • Epidemiology

Background:

  • The menopausal transition involves hormonal fluctuations causing various physical and psychological symptoms.
  • Increased vulnerability to suicidality is a severe potential impact of (peri)menopause for some women.
  • A holistic examination of the link between menopause and suicidality is lacking.

Purpose of the Study:

  • To systematically review the relationship between the menopausal transition and suicidality.
  • To identify menopause-related factors associated with elevated suicide risk.

Main Methods:

  • A systematic review following PRISMA guidelines.
  • Searched MedLine, CINAHL, PsychINFO, Web of Science, and Cochrane Library for relevant studies.
  • Assessed study quality using the Mixed Methods Appraisal Tool.

Main Results:

  • 19 studies (1987-2025) were included; 16 (84%) found an association between menopausal transition and increased suicidality.
  • Seven studies specifically linked perimenopause with higher suicide risk.
  • Key contributing factors identified include hormonal changes, pre-existing mental health issues, physical symptoms, and social support deficits.

Conclusions:

  • Evidence suggests a link between the menopausal transition, particularly perimenopause, and suicidality, though study limitations exist.
  • Integrating mental health support into menopause care is crucial.
  • Further research is needed to understand suicide risk mechanisms during menopause, with enhanced screening and interventions recommended.