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Updated: Jun 7, 2026
09:10
Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
Summary
Iprindole, an antidepressant, was linked to liver damage in 21 patients, causing jaundice and other symptoms. All patients recovered after discontinuing the medication, indicating a reversible drug-induced liver injury.
Area of Science:
- Hepatology
- Clinical Pharmacology
- Psychiatry
Background:
- Antidepressants are widely prescribed for depression.
- Drug-induced liver injury (DILI) is a significant concern in pharmacotherapy.
- Iprindole is a tricyclic antidepressant used for treating major depressive disorder.
Purpose of the Study:
- To investigate the potential hepatotoxicity of iprindole.
- To describe the clinical presentation and histological findings of iprindole-induced liver injury.
- To assess the reversibility of liver damage associated with iprindole treatment.
Main Methods:
- Retrospective analysis of 21 patients treated with iprindole for depression.
- Clinical assessment of liver damage indicators including jaundice, bilirubinuria, and pruritus.
- Liver biopsy with light and electron microscopy in one patient.
Main Results:
- Twenty-one patients exhibited evidence of liver damage following iprindole treatment.
- Common manifestations included jaundice (15 patients), bilirubinuria (5 patients), and pruritus (1 patient).
- Liver biopsy revealed cholestasis without inflammation.
Conclusions:
- Iprindole can cause significant liver injury, manifesting as cholestatic jaundice.
- The observed liver damage appears to be dose-dependent and reversible upon drug withdrawal.
- Hepatotoxicity should be considered in patients treated with iprindole presenting with liver dysfunction.
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