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Updated: Jan 15, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Catalytic Base-Induced Trifluoromethylation of Selenosulfonates and Beyond
Jintao Liang1, Guofang Guo1, Junhong Wang1
1Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, Zhejiang 311121, P. R. China.
Abstract:
The construction of Se-CF3 bonds represents a powerful yet challenging strategy for accessing either alkyl- or aryl-substituted trifluoromethyl selenides, primarily due to the limitation of suitable Se-containing precursors. Herein, we report a catalytic base-induced trifluoromethylation/fluoroalkylation of selenosulfonates using the commercially available Ruppert-Prakash reagent. Furthermore, this transition-metal-free protocol enables the synthesis of a diverse range of trifluoromethyl sulfides.
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