Six-membered cyclic sulfamidate imines: functionalization and cyclization reactions

Six-membered cyclic sulfamidate imines are a class of readily accessible and stable imines that have proven to be important building blocks in constructing functionalized cyclic N-sulfamidates and sulfamidate-fused heterocycles. They can undergo functionalization reactions, such as alkylation, arylation, allylation, alkenylation, alkynylation, amidation, amination, and acylation, as well as cycloaddition reactions with various nucleophiles. The sulfamidate-based compounds show a diverse range of biological activities and are valuable synthetic reagents and intermediates. In this review, we describe the transformations involving cyclic N-sulfimines under various catalysis systems, including transition metal, organocatalysis, base, acid, photocatalysis, and electrocatalysis, as well as catalyst-free conditions.