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Reticular erythematous mucinosis: a systematic review of a controversial entity
Gianmarco D Bigotto1,2, Marco Piras3,4, Sveva Lenti3,4
1Vita-Salute San Raffaele University, Milan, Italy - bigotto.gianmarco@hsr.it.
Introduction:
Reticular erythematous mucinosis (REM) is a rare chronic dermatosis, predominantly affecting middle age women, characterized by net-like macules and patches on the chest and back. The etiology of REM is uncertain, though associations with environmental, hormonal, and autoimmune factors have been suggested.
Evidence Acquisition:
This systematic review of 62 studies, involving 129 patients, analyzes the clinical, histopathological, and therapeutic aspects of REM.
Evidence Synthesis:
Findings indicate consistent mucin deposition in the dermis, a predominant lymphocytic infiltrate, and a frequent association with comorbidities like thyroid disorders and autoimmune diseases. Antimalarial medications, particularly hydroxychloroquine, are highlighted as the most effective treatment, though the disease may relapse upon cessation.
Conclusions:
This review emphasizes REM as a distinct clinical entity and underscores the need for further research to refine diagnostic criteria and treatment protocols.
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