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Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
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Related Experiment Video

Updated: Jan 6, 2026

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
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Left ventricular geometry, brain architecture, and cognition: an observational study.

Pier-Giogio Masci1,2, Maxim Freydin3, Gianni Andreozzi4

  • 1School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK.

European Heart Journal
|October 9, 2025
PubMed
Summary

Cardiovascular health, specifically ventricular geometry, strongly impacts brain structure and cognitive function. Hippocampal volume may mediate this CV-brain link, highlighting its importance in aging.

Keywords:
Cardiac magnetic resonance imagingHeart–brain axisVentricular geometry

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Area of Science:

  • Cardiology
  • Neurology
  • Neuroimaging
  • Gerontology

Background:

  • Cardiovascular diseases and dementia share risk factors and often coexist.
  • Understanding the cardiovascular-brain interaction is crucial for managing health in older adults.

Purpose of the Study:

  • To investigate the relationship between cardiovascular phenotypes, brain structure, and cognitive abilities.
  • To explore the role of hippocampal volume in mediating the cardiovascular-cognition link.

Main Methods:

  • Analysis of 15,519 UK Biobank participants using cardiovascular magnetic resonance imaging (MRI) biomarkers.
  • Confirmatory factor analysis to derive latent variables for cardiac function and geometry (gSyst, gDiast, gGeom) and aortic distensibility (AoD).
  • Multivariable regression models assessed associations with brain MRI phenotypes and cognition, with mediation analysis for hippocampal volume.

Main Results:

  • Cardiac geometry (gGeom) showed the strongest association with hippocampal volume and was the only cardiovascular phenotype linked to better cognition (fluid intelligence, reaction time).
  • Hippocampal volume mediated the positive association between gGeom and cognition.
  • Other cardiovascular phenotypes (gSyst, gDiast, AoD) had weaker associations with brain structure and were not linked to cognition.

Conclusions:

  • Ventricular geometry is a key cardiovascular phenotype associated with brain architecture and cognitive function.
  • Hippocampal volume may play a mediating role in the cardiovascular-cognition relationship, warranting further causal investigation.