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Design and Manufacturing of Piezoelectric Biomaterials for Bioelectronics and Biomedical Applications
Zhuomin Zhang1,2,3, Zhenqi Wang1, Xuemu Li1
1Department of Mechanical and Aerospace Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR 999077, China.
Chemical Reviews
|October 9, 2025
Summary
Piezoelectric biomaterials offer biocompatible alternatives to synthetic materials for energy conversion. This review highlights design and manufacturing strategies to overcome limitations in piezoelectricity and fabrication for biomedical applications.
Area of Science:
- Biomaterials Science
- Materials Engineering
- Bioelectronics
Background:
- The piezoelectric effect facilitates electrical-mechanical energy conversion, crucial for many technologies.
- Synthetic piezoelectric materials (ceramics, polymers) have limitations like rigidity, toxicity, and non-degradability.
- Piezoelectric biomaterials present biocompatible, biodegradable, and eco-friendly alternatives, but face challenges in weak piezoelectricity and scalable fabrication.
Purpose of the Study:
- To critically review recent advancements in piezoelectric biomaterials.
- To focus on design strategies and manufacturing methods for enhanced piezoelectric performance.
- To explore applications in bioelectronics and biomedicine.
Main Methods:
- Summarization of principles, advantages, and categories of piezoelectric biomaterials.
- Exploration of computational studies and molecular engineering approaches.
- Evaluation of various design and manufacturing techniques for piezoelectric enhancement.
Main Results:
- Identified design and manufacturing strategies to improve piezoelectric performance in biomaterials.
- Highlighted cutting-edge applications in bioelectronics and biomedicine.
- Assessed the advantages and limitations of different approaches.
Conclusions:
- Piezoelectric biomaterials show significant promise for biomedical applications.
- Further research is needed in computational modeling, fabrication, characterization, and application development.
- Overcoming current limitations will unlock the full potential of these advanced materials.
