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Tumor Microenvironment T-cell Heterogeneity and Prognostic Model Construction in Laryngeal Squamous Cell Carcinoma by
Xin Pan1, Jianchao Wang2, Fenglei Liu3
1The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Objective:
Characterize T-cell profiles in laryngeal squamous cell carcinoma (LSCC) using single-cell RNA sequencing and develop a prognostic model.
Methods:
ScRNA-seq of LSCC tissues identified T-cell subtypes and marker genes. A prognostic model was constructed using COX and LASSO regressions with TCGA data, validated through bootstrap resampling and GEO dataset.
Results:
Seven T-cell subtypes were detected. The model (HNRNPM, HSPH1, JMJD6, KDM5C, LCK) effectively predicted prognosis and correlated with immune infiltration, tumor mutational burden, and drug sensitivity.
Conclusion:
This study provides insights into T-cell heterogeneity in LSCC and establishes a validated prognostic risk model for predicting survival and therapeutic outcomes.
