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Updated: Jan 15, 2026
Simultaneous Video-EEG-ECG Monitoring to Identify Neurocardiac Dysfunction in Mouse Models of Epilepsy
Published on: January 29, 2018
Preclinical common data elements: a practical guide for use in epilepsy research
Anna-Maria Katsarou1, Vanja Panic2, Melissa Barker-Haliski3
1Albert Einstein College of Medicine, Saul R. Korey Department of Neurology, 1410 Pelham Parkway South, Rose F. Kennedy Center, Rm 310, Bronx, NY 10461, USA.
Abstract:
Although advancements in epilepsy research have yielded new insights into pathophysiology and therapeutic targets, there is an ongoing need for new treatments to combat ongoing pharmacoresistance or offer disease-modifying effects. Variation between preclinical epilepsy research laboratories in methods of data capture, endpoint characterization, and experimental procedures may represent a significant challenge to finding consensus for new information important to the field. Harmonization of data collection approaches by using common data elements (CDEs) within case report forms (CRFs) may aid in reproducibility of preclinical research. Ongoing efforts have expanded the availability of CDEs and CRFs across several research areas. However, establishing such data capture approaches may represent a significant logistical challenge, particularly for new investigators. This commentary provides guidance to implement these approaches, including key points for consideration and providing examples of CDEs and data collection best practices. Our goal is to aid investigators in establishing and utilizing CDEs as part of a developing research program. This guidance may also prove beneficial to established laboratories seeking to harmonize standard operating procedures with other laboratories. Finally, as much of the field of epilepsy research increasingly involves large data sets and multiple study sites, this review may shed light on key points of consideration and alignment across collaborating laboratories.
Insights
Standardizing data collection in preclinical epilepsy research using common data elements (CDEs) and case report forms (CRFs) is crucial for reproducibility. This guidance helps researchers implement these methods to improve consensus and advance epilepsy treatment development.
Area of Science:
- Neuroscience
- Epilepsy Research
- Translational Medicine
Background:
- Despite progress in understanding epilepsy pathophysiology and identifying therapeutic targets, challenges remain in treating pharmacoresistant epilepsy and developing disease-modifying therapies.
- Variability in data capture, endpoint assessment, and experimental protocols across preclinical epilepsy research laboratories hinders consensus and the translation of findings.
- The need for reproducible and harmonized preclinical research is critical for advancing epilepsy treatment development.
Purpose of the Study:
- To provide guidance on implementing common data elements (CDEs) and case report forms (CRFs) for preclinical epilepsy research.
- To address the logistical challenges faced by investigators, particularly new researchers, in adopting standardized data collection approaches.
- To promote harmonization of standard operating procedures across laboratories and facilitate collaboration in large-scale, multi-site epilepsy research.
Main Methods:
- The commentary reviews the importance of CDEs and CRFs in enhancing the reproducibility of preclinical epilepsy research.
- It offers practical guidance, key considerations, and examples for establishing and utilizing CDEs and best practices for data collection.
- The focus is on practical implementation for both new and established research laboratories.
Main Results:
- Standardizing data collection through CDEs and CRFs can significantly improve the reproducibility of preclinical epilepsy research.
- Implementation of these standardized approaches aids in achieving consensus on critical research findings.
- Guidance provided facilitates the adoption of CDEs, supporting the development of robust research programs and collaborative efforts.
Conclusions:
- Adopting common data elements (CDEs) and standardized case report forms (CRFs) is essential for improving the reproducibility and reliability of preclinical epilepsy research.
- This harmonization facilitates consensus-building and accelerates the development of novel epilepsy treatments.
- The guidance presented empowers investigators to implement standardized data collection, fostering collaboration and advancing the field of epilepsy research.
