Gene amplification and protein overexpression of FLNA in head and neck squamous cell carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Filamin A (FLNA) gene amplification and overexpression are common in head and neck squamous cell carcinoma (HNSCC). High FLNA levels correlate with advanced disease and poor prognosis, suggesting FLNA as a potential HNSCC biomarker.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy with known risk factors.
- Filamin A (FLNA), an actin-binding protein, influences cytoskeletal dynamics, but its role in HNSCC remains under investigation.
Purpose Of The Study
- To investigate FLNA gene amplification, mRNA, and protein overexpression in HNSCC.
- To evaluate the clinical significance and prognostic value of FLNA alterations in HNSCC patients.
Main Methods
- Utilized cBioPortal for genetic alterations and UALCAN for expression analysis (TCGA, CPTAC).
- Validated FLNA expression via real-time PCR and immunohistochemistry.
- Performed prognostic analysis using Kaplan-Meier plotter and pathway analysis via Metascape.
Main Results
- FLNA alterations, predominantly amplification, occurred in 7% of HNSCC patients, correlating with increased mRNA expression.
- FLNA mRNA and protein were significantly upregulated in HNSCC tissues compared to non-tumor samples.
- High FLNA expression was linked to advanced stage, higher grade, lymph node metastasis, and reduced overall survival.
Conclusions
- FLNA amplification and overexpression are potential prognostic biomarkers for HNSCC.
- FLNA is implicated in key pathways like focal adhesion and cell adhesion, crucial for cancer progression.
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