Related Experiment Video
Updated: Jan 15, 2026
Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation
Published on: October 11, 2024
Lung transplantation for chronic thromboembolic pulmonary hypertension-a case series
Andrei M Darie1, Atsuo Doi2, Bronwyn J Levvey1
1Lung Transplant Service, Alfred Hospital and Monash University, Melbourne, Australia.
Introduction:
Chronic thromboembolic pulmonary hypertension (CTEPH) is a form of pulmonary vascular disease amenable to multimodal therapy. Pulmonary endarterectomy (PEA) is the cornerstone of CTEPH treatment for operable patients. However, a significant proportion of patients present with inoperable disease or residual postoperative pulmonary hypertension. Lung transplantation (LTx) remains a lifesaving therapy for patients with end-stage right heart failure due to CTEPH.
Methods:
In this case series we describe six cases of CTEPH undergoing LTx at the Alfred Hospital. Half of the patients included in this case series underwent PEA prior to LTx.
Results:
The most frequent finding on explant histology was arterial muscular hypertrophy due to thrombotic arteriopathy. We present the pre-transplant hemodynamic features and discuss the long-term outcomes post-LTx and the surgical challenges that can arise in the context of prior cardiothoracic surgery.
Conclusions:
LTx is a definitive, although rarely utilized therapy, underlining the growing expertise and advancements in specific multimodal therapy for CTEPH.
