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Membrane Guanylyl Cyclases as Potential Targets for Guanylin Action
Elizaveta D Snigireva1, Olga V Smirnova2
1Lomonosov Moscow State University, Moscow, 119991, Russia. ilizotra@gmail.com.
Abstract:
Guanylins are intestinal natriuretic peptides that regulate water and electrolyte balance in the intestine and kidney. Their primary receptor is membrane guanylyl cyclase C (GC-C), while alternative functions related to feeding behavior and olfactory preferences are mediated by guanylyl cyclase D (GC-D) expressed exclusively in olfactory neurons. Evidence suggests existence of unidentified receptors activated by guanylin peptides in the absence of GC-C that affect sodium metabolism. Some of these receptors trigger the cGMP-dependent signaling pathways typical exclusively for guanylyl cyclases. This review provides a comparative analysis of the existing data on different membrane receptor guanylyl cyclases, including early discoveries and contemporary research, focusing on their potential as guanylin targets.
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