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The Prognostic Value of hsCRP in CVD/CKD Among East Asian Population: A Scoping Review
Xiangyi Kong1, Ling Du2, Wenyan Liu2
1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Insights
Elevated high-sensitivity C-reactive protein (hsCRP) is linked to increased cardiovascular disease (CVD) and chronic kidney disease (CKD) risk in East Asians. Higher hsCRP levels also predict major adverse cardiac events (MACE) in these patient groups.
Area of Science:
- Biomedical Science
- Cardiology
- Nephrology
Background:
- Systemic inflammation, indicated by high-sensitivity C-reactive protein (hsCRP), impacts cardiovascular disease (CVD) and chronic kidney disease (CKD).
- The prognostic significance of hsCRP in East Asian populations for CVD and CKD requires further clarification.
Purpose of the Study:
- To conduct a scoping review evaluating the prognostic value of hsCRP for CVD and CKD in East Asian populations.
- To synthesize existing evidence on the association between hsCRP levels and the risk and outcomes of CVD and CKD.
Main Methods:
- Systematic electronic searches were performed in PubMed, Embase, and the Cochrane Library.
- Included were English-language studies published before January 9, 2024, focusing on hsCRP, CVD/CKD, and East Asian populations.
- Protocol pre-registration number: INPLASY202490133.
Main Results:
- A significant majority of studies reported higher hsCRP levels in CVD and CKD patients compared to controls.
- Elevated hsCRP was associated with an increased risk of CVD and CKD incidence.
- Higher hsCRP levels were consistently linked to major adverse cardiac events (MACE) in patients with atherosclerotic CVD, heart failure, and CKD.
Conclusions:
- Elevated hsCRP levels are associated with an increased risk of CVD/CKD and MACE in East Asian populations.
- Further large-scale prospective studies and meta-analyses are recommended to validate these findings.
- hsCRP shows potential as a prognostic biomarker for CVD and CKD in this demographic.
Background:
Systemic inflammation marked by high-sensitivity C-reactive protein (hsCRP) significantly influences cardiovascular disease (CVD) and chronic kidney disease (CKD) progression, yet its prognostic value in the East Asian population remains unclear.
Objectives:
This scoping review evaluates the prognostic value of hsCRP for CVD and CKD within these populations.
Methods:
We conducted electronic searches in PubMed, Embase, and the Cochrane Library. English studies published before January 9, 2024, related to hsCRP and CVD/CKD in East Asian population were included (Protocol pre-registration number: INPLASY202490133).
Results:
A total of 117 studies compared hsCRP levels between CVD/CKD patients and population without CVD/CKD; 30 studies explored the relationship between hsCRP level and CVD/CKD incident, and 125 studies focused on the association between hsCRP level and major adverse cardiac events (MACE) in CVD/CKD patients. Overall, 92.7% (n = 102 of 110) of studies indicated that hsCRP levels in CVD patients were significantly higher than those in population without CVD, with all studies on CKD patients reporting elevated hsCRP levels. Additionally, 75% (n = 21 of 28) of studies found an association between elevated hsCRP level and increased risk of CVD, as did both studies focusing on CKD. Regarding prognosis, 73.3% (n = 77 of 105) of studies linked higher hsCRP to MACE in atherosclerotic CVD patients, 68.8% (n = 11 of 16) in heart failure patients, and 62.5% (n = 5 of 8) in CKD patients. Notably, hsCRP cutoff values were highly heterogeneous, but mainly ranged from 1 to 3 mg/L.
Conclusions:
Our findings suggest that elevated hsCRP levels are associated with increased risk of CVD/CKD and MACE. Well-designed, large-scale prospective studies and subsequent meta-analyses are warranted to further validate these associations.
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