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Multiomics analysis of the Silkworm cocoon shell.
Panagiota Fragkou1, Ioannis Martakos2, Georgia Rouni3
1Department of Biology, National and Kapodistrian University of Athens, Panepistimioupoli Zografou, Athens, 15784, Greece.
Scientific Data
|October 9, 2025
Summary
This study used multiomics to analyze Bombyx mori (silkworm) cocoon shells, revealing insights into species diversification. The findings offer a foundation for future research on silkworm cocoon shell applications.
Area of Science:
- Zoology
- Genomics
- Biochemistry
Background:
- Recent genomic findings highlight variability in Bombyx mori ancestry and cocoon shell color.
- Historical and contemporary silkworm populations present an opportunity to study human-driven diversification.
Purpose of the Study:
- To investigate the human-driven introduction and diversification of Bombyx mori in Europe.
- To characterize the phenomic, proteomic, metabolomic, and lipidomic profiles of Bombyx mori cocoon shells.
Main Methods:
- Combined phenomics, proteomics, metabolomics, and lipidomics analyses.
- Optical and fluorescence imaging of 148 cocoon shells.
- LC-MS/MS analysis of 80 cocoon shell samples.
- Data validation using dimensionality reduction, clustering algorithms, and historical archives.
Main Results:
- Identified an average of 98 ± 13 proteins, 141 metabolites, and 981 lipids in Bombyx mori cocoon shells.
- Characterized overt and covert phenotypic traits through imaging analysis.
- Validated multiomics datasets through rigorous statistical and historical methods.
Conclusions:
- The study provides comprehensive multiomics datasets for Bombyx mori cocoon shells.
- These datasets serve as a foundation for further scientific exploration and exploitation of silkworm resources.
