Prognostic and clinicopathological significance of tertiary lymphoid structure in esophageal squamous cell carcinoma: a systematic review and meta-analysis review
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View abstract on PubMed
Summary
This summary is machine-generated.Tertiary lymphoid structures (TLS) are linked to advanced T stage in esophageal squamous cell carcinoma (ESCC). However, TLS presence predicts better overall and progression-free survival in ESCC patients.
Area Of Science
- Oncology
- Immunology
- Pathology
Background
- Tertiary lymphoid structures (TLS) are immune cell aggregates found in non-lymphoid tissues.
- TLS are increasingly recognized as potential biomarkers for cancer patient outcomes.
- Their specific role in esophageal squamous cell carcinoma (ESCC) requires further systematic evaluation.
Purpose Of The Study
- To conduct an updated meta-analysis evaluating the prognostic and clinicopathological significance of TLS in ESCC.
- To systematically assess the association between TLS and TNM staging, overall survival (OS), and progression-free survival (PFS) in ESCC patients.
Main Methods
- A comprehensive literature search was performed across major databases (PubMed, Embase, Web of Science, Scopus, Cochrane Library) up to June 2024.
- Seven studies with nine datasets were included, analyzing TLS presence against ESCC clinicopathological data and survival.
- Pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using random-effects models.
Main Results
- TLS presence correlated significantly with more advanced T stage (OR = 2.65, p < 0.01) but not N stage (OR = 1.27, p = 0.24).
- TLS were significantly associated with improved OS (HR = 0.49, p < 0.01) and PFS (HR = 0.56, p < 0.01).
- Combined HE staining and IHC assessment of TLS showed a more pronounced favorable prognostic effect (OS HR = 0.40; PFS HR = 0.50).
Conclusions
- The presence of TLS is an independent favorable prognostic factor in ESCC.
- TLS assessment, especially using combined HE and IHC criteria, can refine prognostic predictions for ESCC patients.
- These findings underscore the importance of TLS in understanding ESCC progression and patient outcomes.
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