Related Experiment Video
Updated: Jan 6, 2026
Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
Published on: July 17, 2021
Patterns of lipid profile and genetic variations in South Asians
1Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. rahmanian.md@gmail.com.
Aims:
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, imposing a substantial burden on healthcare systems. Dyslipidemia is a primary risk factor for CVDs. South Asians (SAs) are proven to be more at risk of dyslipidemia and the development of CVDs. In this review, we will provide an overview of dyslipidemia and its various types, followed by a closer examination of the pattern of dyslipidemia in SAs and their associated genetic variations.
Methods:
A PubMed, Scopus, and Web of Science search using the relevant keywords was conducted without any time limitation. Afterwards, the articles were screened based on their title and abstract. The remaining articles were selected for full-text review.
Results:
LDL levels have been found to be similar or lower in SAs than in white Europeans. However, it seems that compared with white Europeans, LDL leads to CVDs at lower serum levels in SAs. Denser and smaller LDL particles in SAs are more atherogenic. In addition, SAs have higher levels of lipoprotein (a) than white Europeans. Also, the rate of hypertriglyceridemia in SAs, affecting as high as 70% of their population, is significantly higher than that of white Europeans. A higher level of HDL is associated with a weaker protective effect in SAs compared with other ethnicities. SAs have variations in genes related to lipid metabolism, such as apoliprotein H, lipoprotein lipase, MBOAT7, SGPP1, SPTLC3, PCSK9, and CELSR2.
Conclusion:
SAs are more prone to dyslipidemia, leading to a higher risk of CVDs compared with other ethnic groups.
Related Concept Videos
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:35Asymmetric Lipid Bilayer
01:31Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
02:26Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
01:35Pedigree Analysis
01:24Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...