Related Experiment Video
Updated: Jan 15, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
The association between systemic immune-inflammatory index and cardiac biomarkers among US population: a
Xinmeng Liu1, Shihao Jin2, Mei Ma3
1Department of Rehabilitation Medicine, Tianjin Chest Hospital, Tianjin, China.
Insights
The systemic immune-inflammatory index (SII) is linked to C-reactive protein (CRP), a marker of inflammation. While SII is not significantly associated with NT-pro BNP in the general population, it shows relevance in specific high-risk cardiac groups.
Area of Science:
- Cardiology
- Immunology
- Biomarker Research
Background:
- The systemic immune-inflammatory index (SII), derived from platelet, neutrophil, and lymphocyte counts, is a novel inflammation marker.
- Its relevance to cardiac disease and association with established cardiac biomarkers in the general population remain unclear.
Purpose of the Study:
- To investigate the cross-sectional association between SII and cardiac biomarkers, specifically C-reactive protein (CRP) and NT-pro BNP.
- To explore these associations in the general US adult population and identify potential effect modification in subgroups.
Main Methods:
- Analysis of data from 3206 US adults (aged 20-85 years) from the 1999-2004 NHANES survey.
- Multivariable linear regression models adjusted for demographics, comorbidities, and lifestyle factors.
- Restricted cubic splines used to examine nonlinearity; subgroup analyses conducted for effect modification.
Main Results:
- A consistent, significant positive association was observed between SII and CRP levels across all models (P < 0.001).
- The initial positive association between SII and NT-pro BNP in unadjusted models was attenuated and became non-significant after full adjustment in the general population.
- Significant positive associations between SII and NT-pro BNP were found in individuals over 55 years old, and in those with myocardial infarction (MI) or angina pectoris (AP).
Conclusions:
- SII is a reliable indicator of inflammation due to its persistent association with CRP.
- The association between SII and NT-pro BNP is specific to certain high-risk cardiovascular subgroups, not the general population.
- SII may hold particular significance in evaluating inflammation within specific cardiovascular disease contexts.
Background:
The systemic immune-inflammatory index (SII), calculated from platelet, neutrophil, and lymphocyte counts, is a novel marker of inflammation potentially relevant to cardiac disease. While cardiac biomarkers are used clinically, the relationship between SII and these markers in the general population is unclear.
Methods:
We analyzed data from 3206 US adults (aged 20-85 years) in the 1999-2004 National Health and Nutrition Examination Survey (NHANES). Multivariable linear regression models, adjusted for demographics, comorbidities, and lifestyle factors, assessed cross-sectional associations of SII with cardiac biomarkers. Nonlinearity was examined using restricted cubic splines. Subgroup analyses explored effect modification.
Results:
SII showed a consistent positive association with C-reactive protein (CRP) levels across all models (All P < 0.001). In contrast, the positive association of SII with NT-pro BNP observed in the unadjusted model (β = 0.20; 95% CI 0.11, 0.29; P < 0.001) was attenuated and became non-significant after full adjustment in the general population. Subgroup analyses showed significantly positive associations between SII and NT-pro BNP specifically in individuals aged > 55 years (β = 0.17; 95% CI 0.014, 0.33), and in those with myocardial infarction (MI) (β = 0.82; 95% CI 0.22, 1.43) or angina pectoris (AP) (β = 0.73; 95% CI 0.19, 1.47). The robust SII-CRP association was confirmed in subgroups. Dose-response relationships were supported by spline analyses.
Conclusions:
SII is persistently associated with CRP levels, supporting its role as an inflammatory indicator. Significant associations between SII and NT-pro BNP were observed only in specific high-risk subgroups (aged > 55 years, MI or AP patients), but not in the fully adjusted general population. These findings suggest SII may have particular relevance in specific cardiovascular contexts.
More Related Videos
08:51Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
06:04Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Coronary Artery Disease I: Introduction
01:21Myocarditis I: Introduction
01:27Myocarditis II: Clinical Features and Diagnostic Tests