Related Experiment Video
Updated: Jan 15, 2026
08:41
Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
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Endothelial dysfunction as a feature of vascular aging.
Nadia Akhiyat1, Elias Hellou1, Ilke Ozcan1
1Department of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
European Journal of Preventive Cardiology
|October 10, 2025
Summary
Vascular aging
Area of Science:
- Cardiovascular Science
- Aging Research
- Vascular Biology
Background:
- Endothelial dysfunction is the earliest sign of vascular aging.
- It can occur even without traditional cardiovascular disease risk factors.
- It elevates the risk for atherosclerosis, cardiovascular diseases, and related complications like stroke or death.
Purpose of the Study:
- To review methods for identifying early endothelial dysfunction.
- To summarize therapies for mitigating vascular aging.
Main Methods:
- Review of emerging and traditional diagnostic markers.
- Summary of current and experimental therapeutic strategies.
Main Results:
- Challenges in identifying early vascular aging.
- Exploration of biologic, imaging, and digital markers.
- Overview of therapeutic interventions.
Conclusions:
- Early detection of endothelial dysfunction is crucial.
- Various methods and therapies are being investigated to manage vascular aging.
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