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Yanyu Zhou1, Lanyang Gao1,2, Chu Jiang1

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This study introduces random-access structural DNA memory using Boolean search. Data is retrieved via magnetic extraction from DNA origami tiles, overcoming previous limitations in DNA data storage.

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Data Storage

Background:

  • Traditional DNA data storage relies on nucleotide sequences, requiring complex synthesis and sequencing.
  • Structural DNA memory uses DNA nanostructures but lacks random-access capabilities.
  • Efficient data retrieval is crucial for practical DNA memory applications.

Purpose of the Study:

  • To develop a random-access scheme for structural DNA memory.
  • To enable Boolean search functionality for data retrieval.
  • To demonstrate efficient data access in complex DNA databases.

Main Methods:

  • Encoding data on DNA origami tiles with multi-dimensional index strands (1D/2D/3D).
  • Implementing Boolean search via hybridization of biotinylated probes to specific index combinations.
  • Utilizing magnetic extraction for targeted data retrieval.
  • Validating data retrieval accuracy using Atomic Force Microscopy.

Main Results:

  • Successful implementation of a Boolean search-enabled random-access system for structural DNA memory.
  • Demonstrated precise retrieval of data from single-, dual-, and triple-indexed libraries.
  • Validated the effectiveness of magnetic extraction for file retrieval.
  • Confirmed data integrity and accuracy through Atomic Force Microscopy.

Conclusions:

  • The developed scheme provides a robust framework for random access in structural DNA memory.
  • This advancement overcomes limitations of previous DNA data storage methods.
  • Enables practical implementation of complex structural DNA databases with efficient data retrieval.