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Updated: Jan 15, 2026

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
No post-infusion reactions after infliximab or vedolizumab
Lars Koch Hansen1, Karina Winther Andersen1, Sara Emmerich Jensen1
1Department of Gastroenterology and Hepatology, University Hospital of South Denmark - Vejle Hospital.
Introduction:
Biologic therapies like infliximab and vedolizumab effectively treat inflammatory bowel disease (IBD), but post-infusion observation consumes considerable clinical resources. This study evaluated whether post-infusion observation periods may be safely reduced or eliminated.
Methods:
A retrospective analysis included all IBD patients receiving infliximab or vedolizumab from January 2019 to December 2020 at Sygehus Lillebaelt, Denmark. Data included infusion counts, observation duration, timing and severity of reactions.
Results:
Among 380 patients receiving 3,847 infusions, 43 reactions (1.1%) occurred exclusively during infusions, mostly within the first 15 minutes. No reactions were reported after infusion had concluded.
Conclusions:
Routine post-infusion observation after infliximab and vedolizumab appears unnecessary. Reducing or eliminating this practice may optimise clinical resources without compromising patient safety.
Funding:
None.
Trial Registration:
Not relevant.
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