A pilot study and histological examination of xenograft and autogenous bone combinations with i-PRF in guided bone
Saurabh Kamat1, Senthil Murugan M2, Edlyn Rodrigues1
1Department of Oral & Maxillofacial Surgery, Goa Dental College and Hospital, Goa , India.
Background:
This study evaluated the impact of different regenerative biomaterial combinations on bone quality and implant stability in guided bone regeneration (GBR).
Methods:
A pilot study was conducted from September 2020 to October 2023 to compare the quality of bone regeneration and implant stability following GBR using three composite graft combinations. Forty-seven patients participated in the study in three experimental groups: group A (deproteinized cancellous bovine bone [xenograft] with injectable platelet-rich fibrin [i-PRF]), group B (xenograft with autogenous bone graft in a 2:1 ratio with i-PRF), and group C (xenograft with autogenous bone graft in a 1:1 ratio with i-PRF). The implant stability quotient (ISQ) was measured at the time of implant placement. Crestal bone biopsy procedures were performed.
Results:
The study found that group C, using a 1:1 ratio of xenograft and autogenous graft with i-PRF, achieved the highest new bone formation (65.83%) and demonstrated moderately high vascularization and osteoclastic activity, indicative of good remodeling potential. ISQ measurements for all groups indicated good primary stability of implants, ranging from 55 to 65 at the time of placement.
Conclusion:
Combining xenograft with autogenous graft in a 1:1 ratio, along with i-PRF, yielded optimal outcomes for new bone formation in GBR procedures. However, further research is needed to address the limitations associated with i-PRF, such as lack of rigidity and faster degradation, to enhance its application in GBR procedures.
