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Related Concept Videos

Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

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Related Experiment Video

Updated: May 7, 2026

A Murine Model of Subarachnoid Hemorrhage
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Perimesencephalic subarachnoid haemorrhage: A case study.

Esaias C C Koller1, Joubert C Steynberg2, Zainub Jooma3,4

  • 1Department of Anaesthesia, Charlotte Maxeke Johannesburg Academic Hostpital, Johannesburg, South Africa.

Journal of the Colleges of Medicine of South Africa
|October 10, 2025
PubMed
Summary

Perimesencephalic subarachnoid hemorrhage (PM-SAH) is a rare, benign condition. A case study identified a superior cerebellar artery fenestration as a potential cause in a patient with PM-SAH.

Area of Science:

  • Neurology
  • Vascular Surgery
  • Radiology

Background:

  • Spontaneous subarachnoid hemorrhage (SAH) is often caused by ruptured aneurysms.
Keywords:
case studyhaemorrhagenon-aneurysmalperimesencephalicsubarachnoid

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  • In 15% of SAH cases, no vascular abnormality is found, categorized as perimesencephalic (PM-SAH) or non-perimesencephalic.
  • PM-SAH is rare, typically has a favorable prognosis, and requires a high index of suspicion for diagnosis.