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In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
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A comparative case study on the performance of global sensitivity analysis methods on digit classification.

Zahra Sadeghi1, Stan Matwin1

  • 1Faculty of Computer Science, Dalhousie University, 6050 University Ave., Halifax, B3H 4R2 NS Canada.

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|October 10, 2025
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Summary

Global sensitivity analysis identifies key input factors for AI models. This study evaluates methods for deep learning, highlighting effective techniques for feature importance in digit classification.

Keywords:
Black-box modelsDeep neural networksDigit classificationExplainable AIFeature selectionGlobal sensitivity analysisInfluential features

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Area of Science:

  • Artificial Intelligence
  • Machine Learning
  • Data Science

Background:

  • Global sensitivity analysis (GSA) aims to identify influential input factors in black-box models.
  • AI explainability seeks to clarify machine learning (ML) behavior by identifying key features.
  • Current GSA methods vary mathematically, leading to diverse conclusions on feature importance.

Purpose of the Study:

  • To examine influential features identified by GSA algorithms.
  • To evaluate the role of these features in deep learning model decision-making.
  • To determine the most suitable GSA methods for ML and deep learning models.

Main Methods:

  • Mathematical foundations of GSA algorithms were presented.
  • A comparative case study of GSA methods was conducted.
  • A methodology was proposed and applied to the MNIST digit dataset classification.

Main Results:

  • The study identified influential features impacting deep learning model decisions.
  • Comparative analysis revealed varying conclusions based on different GSA techniques.
  • The efficacy of GSA methods was evaluated in the context of digit classification.

Conclusions:

  • Certain GSA methods are more effective than others for identifying key factors in deep learning.
  • Understanding feature influence is crucial for accurate decision-making in ML.
  • The study provides insights into selecting appropriate GSA techniques for deep learning applications.