Dextran-Polydopamine Dual Coating on 3D-Printed Polycaprolactone Scaffolds as a Potential Biofunctionalization...

Area of Science:

• Biomaterials Science
• Tissue Engineering
• Nanotechnology

Background:

• Three-dimensional (3D) printing enables patient-specific bone scaffolds, but enhanced bioactivity and drug delivery are needed.
• Polycaprolactone (PCL) scaffolds require surface modification due to hydrophobicity and lack of osteogenic properties.

Purpose of the Study:

• To investigate dextran-polydopamine (PDA) as a dual coating for 3D-printed PCL scaffolds.
• To evaluate the interplay between dextran and PDA for improved biofunctionalization and cell interaction.
• To explore potential for dextran-based drug delivery in bone tissue engineering.

Main Methods:

• Fabrication of 3D-printed PCL scaffolds.
• Dual coating of scaffolds with dextran and polydopamine (PDA).
• Microstructural, topographical, chemical, and mechanical characterization.
• In vitro cell studies using osteoblast-like MG-63 cells.

Main Results:

• Dextran addition to PDA-coated PCL scaffolds prevented PDA aggregation and formed a homogeneous layer.
• The dual coating enhanced cell adhesion and proliferation.
• Scaffold properties were maintained, ensuring maximum cell interaction.

Conclusions:

• The dextran-PDA dual coating is a viable biofunctionalization platform for 3D-printed PCL scaffolds.
• This approach supports enhanced cell interaction and offers potential for dextran-based drug delivery systems.
• The findings advance bone tissue engineering applications by improving scaffold performance.