Related Experiment Video
Updated: Jan 15, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
[Expression of Concern] miR‑221/222 promote malignant progression of glioma through activation of the Akt pathway
Junxia Zhang1, Lei Han2, Youlin Ge1
1Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Abstract:
Following the publication of the above paper, a concerned reader drew to the Editor's attention that, for the immuno-histochemistry images shown in Fig. 6, the Control/PCNA and Control/p27kip1 panels appeared to be duplicates of each other, where the results of differently performed experiments were intended to have been portrayed. The authors were contacted by the Editorial Office to offer an explanation for this potential anomaly in the presentation of the data in this paper, although up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further. [International Journal of Oncology 36: 913‑920, 2010; DOI: 10.3892/ijo_00000570].
Related Concept Videos
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
PI3K/mTOR/AKT Signaling Pathway
Mitogens and the Cell Cycle
Abnormal Proliferation
MAPK Signaling Cascades
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

