Related Experiment Video
Updated: Jan 15, 2026
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
935
Radioactive iodine for differentiated thyroid carcinoma.
Saumya Sunny1, Kathryn Graham2, Julie Hephzibah1
1Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Current Opinion in Endocrinology, Diabetes, and Obesity
|October 10, 2025
Summary
Radioactive iodine (RAI) may be safely omitted in many low-risk differentiated thyroid cancer (DTC) cases. Management for intermediate-risk DTC is evolving, with molecular genotyping guiding future RAI decisions.
Area of Science:
- Oncology
- Nuclear Medicine
- Endocrinology
Background:
- Radioactive iodine (RAI) is utilized in differentiated thyroid cancer (DTC) for thyroid remnant ablation and residual disease treatment.
- Current guidelines for RAI use in DTC vary, necessitating a review focused on low-risk DTC and randomized trials.
Purpose of the Study:
- To compare guidelines on the use of RAI in DTC.
- To focus on randomized trials in low-risk DTC.
- To explore molecular genotyping's role in advanced RAI-refractory DTC.
Main Methods:
- Review of guidelines and randomized trials concerning RAI use in DTC.
- Analysis of data from ESTIMABL2 and IoN trials.
- Consideration of molecular genotyping in advanced DTC.
Main Results:
- The ESTIMABL2 and IoN trials suggest surveillance is adequate for low-risk DTC post-thyroidectomy.
- RAI practice is becoming risk-adapted, with tailored activity and dosimetry.
- Systemic therapy choices are crucial for RAI-refractory DTC.
Conclusions:
- RAI use in DTC is shifting to a risk-adapted approach.
- Evidence supports withholding RAI in many low-risk DTC patients.
- Optimal management for intermediate-risk DTC requires further research, potentially utilizing molecular data.
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