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Updated: Jan 15, 2026

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
A poly(2-ethyl-2-oxazoline)-based AIE-active photosensitizer with aggregation-enhanced reactive oxygen species for
Abstract:
Developing efficient photosensitizers (PSs) with enhanced reactive oxygen species (ROS) generation capability in the aggregated state is essential for effective photodynamic therapy (PDT). Here, we designed an amphiphilic poly(2-ethyl-2-oxazoline)-based copolymer (PN-TPA-yne) for the first time by conjugating with aggregation-induced emission (AIE)-active PS (TPA-T-yne) using amino-yne click chemistry. The resultant PN-TPA-yne forms water-soluble nano-assemblies with robust AIE and efficient ROS generation, thereby enhancing PDT efficacy and resolving the major issues of conventional PSs.
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