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Home
Development Of Microvascular Network In Microfluidic Brain-on-a-chip Models In Vitro: A Multidisciplinary Review.

Home
Development Of Microvascular Network In Microfluidic Brain-on-a-chip Models In Vitro: A Multidisciplinary Review.

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Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

Development of Microvascular Network in Microfluidic Brain-on-a-Chip Models In Vitro: A Multidisciplinary Review.

Alla B Salmina^1,2, Mikis R Saridis¹, Vitaly V Ryzhkov^1,3

¹Bauman Moscow State Technical University, Moscow, Russia.

Biotechnology Journal

|October 10, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Researchers developed a novel brain-on-a-chip model using an electric field to stimulate blood vessel growth. This advancement aims to create realistic brain tissue for personalized medicine and drug testing.

Keywords:

angiogenesis blood–brain barrier microfluidics organ‐on‐a‐chip vascularization

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Published on: May 19, 2016

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

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Published on: April 4, 2018

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Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Published on: April 4, 2018

Area of Science:

Biomedical Engineering
Neuroscience
Vascular Biology

Background:

Microfluidic brain-on-a-chip and angiogenesis-on-a-chip models show promise but lack physiological relevance for personalized medicine and drug development.
Creating in vitro brain models with in vivo structural and functional characteristics, including barrier integrity and plasticity, is a significant biomedical engineering challenge.

Purpose of the Study:

To review current knowledge on brain microvascular network formation and cerebral angiogenesis.
To analyze novel approaches for reconstructing brain angiogenesis and barrier genesis in a physiologically relevant brain-on-a-chip model.
To present a novel concept using external electric fields to stimulate vasculogenesis/angiogenesis on-chip.

Main Methods:

Review of existing literature on brain-on-a-chip and angiogenesis-on-a-chip models.

Analysis of in vivo microvascular network formation and cerebral angiogenesis mechanisms.

Proposal and analysis of an external electric field stimulation method for on-chip vasculogenesis/angiogenesis.

Main Results:

Identified challenges in replicating in vivo brain tissue complexity and barrier function in current chip models.
Highlighted the need for a multidisciplinary approach integrating diverse scientific fields.
Demonstrated the potential of external electric field stimulation for controlled vascularization in brain-on-a-chip systems.

Conclusions:

A synergistic, multidisciplinary approach is crucial for developing advanced brain-on-a-chip models.
External electric field stimulation offers a promising strategy to establish vascularized brain tissue on-chip.
This novel approach could lead to more accurate drug testing and personalized diagnostics.