Influence of Cannabidiol Use on Visual Function and Optical Quality: A Randomized Controlled Trial

Area of Science:

• Ophthalmology
• Pharmacology
• Neuroscience

Background:

• Cannabidiol (CBD) is a non-psychotropic compound found in cannabis.
• Research into CBD's effects on physiological functions, including vision, is ongoing.
• Understanding CBD's impact on visual performance is crucial for public health and safety.

Purpose of the Study:

• To investigate the influence of varying vaporized CBD concentrations (0%, 15%, 30%) on human visual function and optical quality.
• To assess potential adverse effects of CBD on visual acuity, contrast sensitivity, and other visual parameters.
• To evaluate the safety of short-term CBD use concerning visual performance.

Main Methods:

• A randomized, crossover, double-blind, placebo-controlled study involving 30 participants.
• Administration of placebo, 15% (16 mg), and 30% (32 mg) CBD concentrations via vaporization.
• Comprehensive visual function tests (visual acuity, contrast sensitivity, pupil size, etc.) and optical quality assessments (MTF, OSI, etc.).

Main Results:

• No significant impairment in static and dynamic visual acuity was observed.
• Contrast sensitivity, dot motion detection, and visual disturbance index remained unaffected by CBD.
• Optical quality parameters, stereoacuity, and pupil size showed no deterioration or changes after CBD consumption.

Conclusions:

• Short-term use of vaporized CBD at assessed concentrations does not adversely affect vision.
• CBD is a non-psychotropic substance that appears safe for vision in the short term.
• Findings support the safety of CBD for activities requiring visual function.