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Related Experiment Video

Updated: Jan 15, 2026

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

Published on: February 9, 2024

FAM72A Promotes Colorectal Cancer Progression by Regulating Reactive Oxygen Species and Inhibiting Cellular

Guorui Ma¹, Guanwei Yin², Xinlin Wu¹

¹Department of Gastrointestinal Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

Digestive Diseases and Sciences

|October 10, 2025

Summary

FAM72A promotes colorectal cancer (CRC) progression by inhibiting pyroptosis via reduced ROS. Targeting FAM72A offers a potential therapeutic strategy for CRC patients.

Keywords:

Colorectal cancer FAM72A Pyroptosis Reactive oxygen species

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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Area of Science:

Oncology
Molecular Biology
Cellular Biology

Background:

Colorectal cancer (CRC) presents a significant global health challenge with complex mechanisms.
Identifying novel molecular targets is crucial for effective CRC treatment.
FAM72A's role in CRC pathogenesis requires detailed investigation.

Purpose of the Study:

To investigate FAM72A expression in CRC.
To elucidate FAM72A's mechanism in regulating cancer cell proliferation and invasion.
To explore FAM72A's impact on cellular pyroptosis.

Main Methods:

Bioinformatic analysis of FAM72A expression and prognosis in CRC.
In vitro studies involving FAM72A knockdown and overexpression in CRC cell lines.
Assessment of cell proliferation, invasion, pyroptosis markers, and ROS levels.
In vivo tumor growth experiments in nude mice.

Main Results:

Elevated FAM72A expression correlates with poor CRC prognosis.
FAM72A knockdown suppressed CRC cell proliferation, migration, and invasion while activating pyroptosis.
FAM72A overexpression enhanced proliferation and invasion by inhibiting pyroptosis.
Reactive oxygen species (ROS) mediate FAM72A's effects on pyroptosis and CRC progression.

Conclusions:

FAM72A inhibits cellular pyroptosis by reducing ROS levels.
This inhibition promotes CRC cell proliferation and invasion.
FAM72A represents a potential therapeutic target for colorectal cancer.