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Resistant Blood Pressure: New Frontiers in Interventional Hypertension Therapy
Jeffrey D Taylor1, Chukwunonyelum Uche2, Vanessa Rowe2
1Department of Cardiology, University of Illinois Chicago, Chicago, IL, USA. jtaylo68@uic.edu.
Cardiology and Therapy
|October 10, 2025
Summary
Interventional therapies targeting sympathetic overactivity offer new hope for managing difficult hypertension. Renal denervation shows promise, but secondary causes must be ruled out first.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Neurology
Background:
- Hypertension affects over 1.3 billion globally, a major cause of cardiovascular disease.
- Sympathetic overactivity and autonomic dysregulation are key in hypertension development.
- Interventional device-based therapies are emerging for hypertension management.
Purpose of the Study:
- To review evolving interventional device-based therapies for hypertension.
- To highlight the role of these therapies in resistant hypertension (RH).
- To emphasize the importance of managing secondary hypertension causes.
Main Methods:
- Overview of current interventional approaches: renal denervation (RDN), baroreceptor activation therapy (BAT), carotid body modulation, hepatic denervation, cardiac neuromodulation.
- Review of clinical trial evidence for these therapies.
- Discussion on the necessity of diagnosing secondary hypertension.
Main Results:
- RDN has the most substantial clinical trial evidence among interventional therapies.
- Other neuromodulatory strategies are in early-phase studies.
- Systematic identification and management of secondary hypertension are crucial before interventions.
Conclusions:
- Interventional therapies show potential as adjuncts for hypertension management, particularly RH.
- RDN is the most established interventional therapy currently.
- Future precision-based hypertension management may incorporate these advanced therapies.
Keywords:
Baroreceptor activationEndovascular therapyInterventional cardiologyInterventional therapyRenal denervationResistant hypertensionSecondary hypertensionMore Related Videos
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